Working Group Prof. Dr. Josef Köhrle

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Field of Research

  • molecular aspects of the TH axis, TH biosynthesis and metabolism
  • Effects of endocrine active compounds upon the TH axis
  • interaction between trace elements and the endocrine system

Recent Publications

Hoefig CS, Wuensch T, Lehmphul I,  Daniel H, Schweizer U, Mittag J, Köhrle J (2015) Biosynthesis of 3-iodothyronamine from L-thyroxine in murine intestinal tissue. Endocrinology 156(11):4356-64. doi: 10.1210/en.2014-1499.

Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Köhrle J, Schomburg L. (2015) An improved non-radioactive screening method identifies genistein and xanthohumol as potent inhibitors of iodothyronine deiodinases. Thyroid 2015;25:962-8.

Jayarama-Naidu R, Johannes J, Meyer F, Wirth E, Schomburg L, Köhrle J, Renko K. (2015) A nonradioactive uptake assay for rapid analysis of thyroid hormone transporter function. Endocrinology 156:2739-2745.

Rathmann D*, Rijntjes E*, Lietzow J, Köhrle J. (2015) Quantitative analysis of thyroid hormone metabolites in cell culture samples using LC-MS/MS.  European Thyroid Journal 4(suppl 1):51-58. * contributed equally.

Jonas W, Lietzow J, Wohlgemuth F, Hoefig CS, Wiedmer P, Schweizer U, Köhrle J*,  Schürmann A* (2015) 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology 156(1):389-99 * contributed equally

Schweizer U, Schlicker C, Braun D, Köhrle J, Steegborn C. (2014) The Crystal Structure of Mammalian Selenocysteine-Dependent Iodothyronine Deiodinase Suggests a Peroxiredoxin-like Catalytic Mechanism, PNAS 111:10526-31

Lehmphul I, Brabant G, Wallaschofski H, Ruchala M, Strasburger CJ, Köhrle J, Wu Z. (2014) Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody based chemiluminescence immunoassay. Thyroid 24:1350-60.

Selected Original Research Papers

 

1. Behne D, Kyriakopoulos A, Meinhold H, Köhrle J 1990 Identification of Type I Iodothyronine 5'-Deiodinase as a Selenoenzyme. Biochem Biophys Res Commun 173(3):1143-1149

2. Friesema ECH, Grueters A, Biebermann H, Krude H,  Moers A von, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MA, Kuiper GGJM, Balkassmi S, Uitterlinden AG, Köhrle J, Rodien P, Halestrap AP, Visser TJ (2004) Severe X-linked psychomotor retardation caused by mutations in a thyroid hormone transporter. Lancet 364: 1435-1437

3. Schomburg L, Schweizer U, Holtmann B, Flohe L, Sendtner M, Köhrle J. 2003 Gene disruption discloses role of Selenoprotein P in selenium delivery to target tissues. Biochem J 370:397-402

4. Boege F, Straub T, Kehr A, Boesenberg C, Wachsmut A, Christiansen K, Andersen A, Jakob F,  Köhrle J 1996 Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J.Biol.Chem. 271(4) 2262-2270

5. Schmutzler C, Winzer R, Meissner-Weigl J, Köhrle J 1997 Retinoic acid increases sodium/iodide symporter mRNA levels in human thyroid cancer cell lines and suppresses expression of functional symporter in non-transformed FRTL5- rat thyroid cells. Biochem. Biophys. Res. Commun. 240:832-838; Erratum in: Biochem Biophys Res Commun 246:562

Important Reviews

Schweizer U, Köhrle J (2013) Function of thyroid hormone transporters in the central nervous system. BBA - General Subjects, 1830(7):3965-73, invited review

Piehl S, Hoefig CS, Scanlan TS, Köhrle J. (2011) Thyronamines - Past, Present, and Future. Endocrine Reviews 32:64-80

Köhrle J. (2008) Environment and endocrinology: The case of thyroidology.

Ann Endocrinol (Paris). 69(2):116-22. Epub 2008 Apr 28.

Köhrle J, Jakob F, Contempré B, Dumont JE (2005) Selenium, the Thyroid, and the Endocrine System. Endocrine Reviews 26 (7):944–984, (invited review).

Schomburg, L, Schweizer, U, Köhrle J. 2004 Selenium and Selenoproteins in mammals - extraordinary, essential, enigmatic. Cell Mol Life Sci 61:1988-95

Books

Ganten D , Ruckpaul K, Köhrle J. (eds.) Molekularmedizinische Grundlagen von Endokrinopathien II: Para- und Autokrine Regulation (2006) Springer Verlag. 615pp.